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In a most preferred embodiment, said anti-angiogenesis effect may be achieved indirectly, for example, through the inhibition of hematopoietic, tumor-specific cells, such as tumor-associated macrophages (See Joseph I B, et al

Glutathione stands apart from many other antioxidants because it also participates directly in detoxification

The composition of tumor-infiltrating lymphocytes depends on many factors, including tumor type, localization, stage, stemness, and response to previous therapy

Ascorbate peroxidase gene expression during stress led to salt and heat tolerance with no significant changes in levels of other ROS scavenging enzymes (Gueta-Dahan et al., 2007)

At the same time, similarly to human patients, the animals with the ocular hypertension model showed an increase in zinc levels in AH reaching 141 19 g/L at day 7 after induction

Author contributions WL and BW carried out experimental work, analyzed the data, and wrote the manuscript